CSF1R antibody (FineTest®700)

Catalog No. ABIN7675085

This anti-CSF1R antibody is a Rat Monoclonal antibody detecting CSF1R in FACS. Suitable for Mouse.

Quick Overview for CSF1R antibody (FineTest®700) (ABIN7675085)

Target: CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This CSF1R antibody is conjugated to FineTest®700

Application: Flow Cytometry (FACS)

Clone: AFS98

Product Details anti-CSF1R Antibody (FineTest®700)

Purpose: FineTest®700 Anti-Mouse CD115/CSF-1R Antibody

Isotype: IgG2a, kappa

Application Details

Application Notes: Volume per test: 5μL. Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 μL of antibody per test (million cells in 100 μL staining volume or per 100 μL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0. 1 % sodium azide, 1 %BSA, pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: 4 °C

Storage Comment: 2-8°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for CSF1R

Target: CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))

Alternative Name: CD115

Background:

Synonyms: CD115|CSF-1 receptor (EC:2.7.10.1)|CSF-1-R|CSF-1R|Csf1r|Csfmr|Fms|M-CSF-R|Macrophage colony-stimulating factor 1 receptor|Proto-oncogene c-Fms

Background: CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.

Molecular Weight: 0

Gene ID: 12978

UniProt: P09581

Pathways: RTK Signaling, Inositol Metabolic Process, Cell-Cell Junction Organization